Not a good idea, IMO. 22 inches wide is to too wide to hope that it will not move enough to cause problems. The connectors should still pull the top down tight against the aprons so it should still be nice and solid. The idea with different connectors that allow for expansion is to hold everything nice and tight but allow lateral movement across the grain. Glue will not let it move. You can apply glue on the middle 6 to 9 inches but you have to allow the wood on the edges (across the the grain) move or it could either buckle or pull itself apart.